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PFA Static Mixers
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PFA Static Mixers

Price range: $551.00 through $1,285.00

PFA Static Mixers are high-purity, chemically inert inline mixing devices made entirely from Perfluoroalkoxy (PFA) fluoropolymer.

What Are PFA Static Mixers?

They consist of a PFA tube housing fixed internal mixing elements (usually helical or corrugated).
As fluids flow through the mixer, the elements divide, rotate, and recombine the streams to create thorough, uniform mixing without any moving parts.

PFA offers nearly universal chemical resistance and extremely low extractables, making these mixers ideal for ultra-corrosive, high-purity, or contamination-sensitive processes.

Key Benefits

Universal Chemical Resistance Nearly inert to all acids, solvents, and aggressive chemicals.
Ultra-High Purity Extremely low extractables and leachables.
Non-Metallic Eliminates risk of metallic contamination.
No Moving Parts Maintenance-free and highly reliable.

PFA Static Mixers are the preferred choice for ultra-pure and highly corrosive applications in semiconductor, pharmaceutical, and specialty chemical processes where contamination or material degradation cannot be tolerated.

SKU: 32006000 Categories: , Tags: , , , , , , , , , , , , , Brand:

PFA Static Mixers are high-purity, chemically inert inline mixing devices made from Perfluoroalkoxy (PFA), a fluoropolymer material.
They are specifically designed for ultra-corrosive, high-purity, or ultra-clean applications where even trace contamination or material degradation cannot be tolerated.

What Are PFA Static Mixers?

PFA Static Mixers consist of a PFA tube or pipe housing containing fixed internal mixing elements, usually helical (twisted ribbon) or corrugated.
As fluids flow through the mixer, the elements repeatedly divide, rotate, and recombine the flow streams, creating thorough and uniform mixing without any moving parts.

PFA (Perfluoroalkoxy) is a melt-processable fluoropolymer that offers almost universal chemical resistance, extremely low extractables, and excellent thermal stability.
Because of these properties, PFA Static Mixers are widely used in industries where conventional stainless steel or plastic mixers would corrode, contaminate the product, or fail prematurely.

Key Benefits

Universal Chemical Resistance Nearly inert to all acids, bases, solvents, and aggressive chemicals, including HF, aqua regia, and strong oxidizers.
Ultra-High Purity Extremely low extractables and leachables, making them ideal for semiconductor, pharmaceutical, and high-purity chemical processes.
Non-Stick Surface Excellent release properties reduce buildup and simplify cleaning.
Wide Temperature Range Continuous service from -320°F to 500°F (-196°C to 260°C).
No Metal Contact Eliminates risk of metallic contamination in ultra-pure processes.
Corrosion-Free Operation No degradation even with the most aggressive chemicals over long periods.

Common Applications

  • Semiconductor manufacturing – ultra-pure chemical blending, wafer etching solutions, photoresist mixing
  • Pharmaceutical and biotech – high-purity buffer preparation, API intermediates, sterile solvent handling
  • Fine chemical processing – handling strong acids (HF, HCl, HNO₃), oxidizers, and specialty solvents
  • High-purity water systems – ultrapure water (UPW) chemical dosing
  • Laboratory and pilot plants – aggressive or high-purity research processes
  • Specialty gas and liquid chemical delivery systems

PFA Static Mixers represent the highest level of chemical inertness and purity available in static mixing technology.
Their non-metallic, fluoropolymer construction makes them virtually immune to corrosion and contamination, allowing safe and reliable mixing of the most aggressive or ultra-pure fluids where stainless steel or other plastics would fail.

Weight N/A
Dimensions N/A
Size

1/2", 3/4", 1"
Element Qty

6, 12
Element Type

Blade, Helical
Connection Ends

Threaded (MNPT), Flanged (RF150), Plain Ends
Injection Ports (Separate attachment)

0 (Default), 1/4", 1/2"
Flow Straightening Blade

No (Default), Yes
Material

PFA
Removable Elements

Included (Default)

Specifications

PFA Static Mixers are high-purity, chemically inert inline mixing devices made from Perfluoroalkoxy (PFA) fluoropolymer.
They are specifically engineered for ultra-corrosive, high-purity, or contamination-sensitive processes where stainless steel or other plastics would fail.

Detailed Specifications – PFA Static Mixers

Parameter Specification Notes
Material of Construction Perfluoroalkoxy (PFA) – fully fluorinated polymer Highest chemical inertness and purity available
Available Sizes ¼” to 6″ (DN6 to DN150) Larger sizes available on request
Mixing Elements Helical (twisted ribbon) or corrugated/tabbed elements Fixed elements – no moving parts
Connection Types Flared tube ends, Compression fittings, Tri-Clamp (sanitary), Flanged (PTFE-lined or pure PFA) Designed for easy, leak-free connections in high-purity systems
Pressure Rating Up to 150 PSI (10 bar) at ambient temperature Derated at elevated temperatures
Temperature Rating -320°F to 500°F (-196°C to 260°C) Continuous service temperature up to 400°F (204°C) typical
Chemical Compatibility Nearly universal resistance to all acids, bases, solvents, oxidizers, and aggressive chemicals including HF and aqua regia One of the most chemically inert materials available
Purity Level Ultra-low extractables and leachables Suitable for semiconductor (UPW) and pharmaceutical applications
Surface Finish Smooth, non-stick PFA surface Excellent release properties reduce fouling
Pressure Drop Low to moderate (typically 1–5 psi at design flow) Depends on viscosity, flow rate, and number of elements
Applications Semiconductor wet chemicals, pharmaceutical high-purity processes, strong acid/alkali dosing, ultra-pure water systems, specialty gas delivery Best for processes where contamination or corrosion must be completely avoided

PFA Static Mixers are custom-engineered based on flow rate, viscosity, required mixing uniformity, and system pressure/temperature.
Their melt-processable fluoropolymer construction allows for complex geometries while maintaining exceptional chemical inertness and purity.

These mixers are the ultimate choice when stainless steel or other plastics cannot meet the demands of ultra-corrosive or high-purity processes.

Table

PFA Static Mixer Technical Specifications

ModelPipe Dia. MNPT EndsFlow GPMMax PSIG @ 85 FNumber of Elementspsig DropRemovable ElementLengthWeight
0.5-PFA-80-6-MNPT1/2"0.61-5.424560.22-9.7No6"0.16
0.5-PFA-80-12-MNPT1/2"0.61-5.4245120.46-19.8No10"0.32
0.75-PFA-80-6-MNPT3/4"1.21-13.822060.22-9.7No7"0.24
0.75-PFA-80-12-MNPT3/4"1.21-13.8220120.45-19.2No13"0.44
1.0-PFA-80-6-MNPT1"2.2-17.819460.27-11.25No9"0.46
1.0-PFA-80-12-MNPT1"2.2-17.8194120.55-22.1No16"0.82

Pressure Drop

Pressure Drop vs. Flow Rate

PFA Static Mixer – 2″ Nominal Size
Fluid: Water (1 cP viscosity) at 68°F (20°C)

Typical Pressure Drop Curve – PFA Static Mixer

Flow Rate (GPM)   |   Pressure Drop (psi)
─────────────────────────────────────────────
10            |    1.2
20            |    3.8
30            |    7.5
40            |   12.2  ← Typical Design Point
50            |   18.0
60            |   24.5
70            |   31.8
80            |   40.0

PFA Static Mixers (typically helical or corrugated element design) produce moderate pressure drop.
Recommended design range: 8 – 25 psi for effective mixing in high-purity and corrosive services.

Key Notes on Pressure Drop for PFA Static Mixers

  • PFA Static Mixers generally have moderate pressure drop — higher than vane flow straighteners but lower than Shell & Tube designs.
  • Pressure drop increases with the square of the flow rate and rises sharply with higher viscosity fluids.
  • The soft nature of PFA requires careful element design to balance good mixing performance with acceptable pressure loss.
  • Common target pressure drop for process design is 8 – 25 psi to achieve thorough mixing without excessive pumping costs.
  • For ultra-pure or highly corrosive services (semiconductor, pharma), slightly higher pressure drop is often accepted to ensure complete mixing and prevent dead zones.
  • Actual values depend on element type (helical vs. corrugated), number of elements, and specific process conditions.

PFA Static Mixers are widely used in high-purity and aggressive chemical applications where excellent chemical resistance and low extractables are required.
The pressure drop curve helps engineers properly size the chemical feed pump and ensure the mixer delivers the required mixing uniformity.

For precise pressure drop data tailored to your exact flow rate, fluid viscosity, temperature, and PFA mixer configuration, consult the manufacturer for a custom calculation.

Installation

Proper installation of PFA Static Mixers is critical for maintaining chemical purity, preventing leaks, and ensuring optimal mixing performance.
Because PFA is a soft fluoropolymer, special care must be taken to avoid damaging the material during handling and tightening.

Installation Procedures for PFA Static Mixers

Step Installation Procedure Tools / Materials Required Safety & Important Notes
1 Verify the flow direction arrow on the PFA mixer body matches the actual process flow. PFA static mixers are directional — reverse installation will greatly reduce mixing efficiency. None Always confirm flow direction before installation.
2 Shut down the system, isolate the line, depressurize, and follow lockout/tagout (LOTO) procedures. Lockout/Tagout kit Never install while the line is pressurized or contains hazardous chemicals.
3 Clean all connection faces thoroughly. Use only new, compatible gaskets or flared tube fittings rated for PFA systems. Avoid metal-to-PFA contact that could damage the soft material. Lint-free cloths, isopropyl alcohol, new PFA-compatible gaskets or flare fittings PFA is soft — never use abrasive tools or overtighten connections.
4 For flanged or Tri-Clamp connections: Hand-tighten first, then use a calibrated torque tool to achieve even, gentle torque as specified by the manufacturer. For flared tube connections, follow proper flaring procedures. Calibrated torque wrench (low torque settings), flaring tool if applicable Overtightening can deform or crack PFA components.
5 Support the mixer properly to prevent stress on the PFA body. Use non-metallic or lined supports if possible to avoid scratching the material. Proper piping supports or brackets PFA is relatively soft — unsupported weight can cause deformation over time.
6 Perform a low-pressure leak test with compatible fluid or nitrogen before introducing the full process chemical. Check all connections carefully. Pressure testing equipment Start at low pressure and gradually increase while monitoring for leaks.
7 Slowly introduce the process fluid and monitor pressure drop and mixing performance. Verify flow direction and check for any signs of stress on the PFA body. Pressure gauges, flow indicators PFA can be sensitive to sudden pressure or temperature changes.
8 Document the installation, including torque values, gasket/fitting type, pressure test results, and baseline pressure drop in the equipment log. Include photos of the installed mixer. Installation checklist, camera Record serial number and installation date for traceability.

Important Notes for PFA Static Mixers:

• PFA is a soft fluoropolymer — never overtighten connections. Use low, even torque and always follow the manufacturer’s recommendations.
• Use only PFA-compatible gaskets or pure flared tube fittings. Avoid metal-to-PFA direct contact that could damage the material.
• Support the mixer properly to prevent stress or sagging of the PFA body.
• Start with low pressure and flow during initial startup to check for leaks and verify performance.

Correct installation protects the integrity of the PFA material and ensures the mixer delivers the designed mixing performance with maximum purity and safety.

Maintenance

PFA Static Mixers have no moving parts, making them inherently reliable. However, because they are often used in ultra-pure or highly aggressive chemical processes, regular inspection and gentle cleaning are essential to maintain purity, prevent buildup, and ensure long-term performance.

Maintenance Procedures for PFA Static Mixers

Maintenance Task Procedure & Frequency
Daily / Visual Inspection • Check for any external leaks at connections
• Monitor pressure drop across the mixer (if gauges are installed)
• Visually inspect the PFA body for discoloration or damage
Weekly Cleaning • Flush the mixer with ultrapure water or a compatible solvent
• Wipe external surfaces gently to remove any residue
• Check that all connections remain tight
Monthly Deep Cleaning • Isolate the mixer and perform a thorough chemical cleaning cycle using a validated procedure
• Inspect the internal mixing elements (if removable) for any buildup
• Verify that the PFA surface remains smooth and non-stick
Quarterly / Semi-Annual Inspection • Check all connections and fittings for signs of stress or deformation
• Inspect the PFA body for crazing, discoloration, or swelling
• Measure and record pressure drop to detect any internal fouling
Annual / Major Maintenance • Remove the mixer if possible and perform a full inspection
• Clean the internal elements thoroughly (use only approved methods for PFA)
• Replace any gaskets or flared fittings if showing signs of wear
• Pressure test the unit after reassembly
After Chemical Change or Long Shutdown • Thoroughly flush the mixer with compatible solvent or ultrapure water before and after shutdowns
• Inspect for any chemical attack or residue buildup
• Re-verify pressure drop and mixing performance after restart

Important Notes for PFA Static Mixers:

• PFA is chemically inert but soft — use only gentle cleaning methods and avoid abrasive tools or high-pressure water jetting that could damage the surface.
• Monitor pressure drop trends closely. A gradual increase usually indicates internal fouling that needs attention.
• Use only chemicals and cleaning agents proven compatible with PFA. Some solvents can cause swelling or stress cracking if misused.
• For ultra-pure applications, cleaning and maintenance should follow validated protocols to maintain product purity.

Because PFA Static Mixers are often used in critical high-purity or highly corrosive processes, keeping detailed maintenance records is strongly recommended.

Q&A

Question Answer
What is a PFA Static Mixer? A PFA Static Mixer is an inline mixing device made entirely from Perfluoroalkoxy (PFA) fluoropolymer. It uses fixed internal helical or corrugated elements to thoroughly blend fluids without any moving parts. PFA provides nearly universal chemical resistance and ultra-high purity.
Why choose PFA over stainless steel or other plastic static mixers? PFA offers the highest level of chemical inertness available. It resists virtually all acids (including HF), bases, solvents, and oxidizers where stainless steel would corrode and other plastics would degrade or leach contaminants.
What industries use PFA Static Mixers? They are primarily used in semiconductor manufacturing, pharmaceutical and biotech, fine chemical processing, and any ultra-pure or highly corrosive applications where contamination or material degradation cannot be tolerated.
What temperature and pressure ratings do PFA Static Mixers typically have? They typically handle temperatures from -196°C to +260°C (-320°F to +500°F) and pressures up to 10 bar (150 PSI), depending on size and connection type. Ratings are lower at elevated temperatures.
Are PFA Static Mixers suitable for high-purity applications? Yes. PFA has extremely low extractables and leachables, making it one of the best materials for ultra-pure water (UPW), semiconductor wet chemicals, and pharmaceutical processes where metallic or organic contamination must be avoided.
How do PFA Static Mixers compare to PTFE Static Mixers? PFA is melt-processable, allowing more complex shapes and better weldability than PTFE. It also has slightly better mechanical properties and clarity while maintaining nearly identical chemical resistance. PFA is generally preferred for static mixers.
What connection types are available for PFA Static Mixers? Common connections include flared tube ends, compression fittings, sanitary Tri-Clamp, and PTFE-lined flanges. These are chosen to maintain the high-purity integrity of the system.
Do PFA Static Mixers require much maintenance? Very little. Since there are no moving parts, maintenance is mainly limited to periodic flushing or gentle cleaning to prevent buildup. The non-stick surface of PFA helps minimize fouling.
Can PFA Static Mixers handle abrasive slurries? They can handle light slurries, but are not ideal for highly abrasive applications. The soft PFA surface can wear over time with heavy solids. Stainless steel or Hastelloy mixers are usually better for abrasive services.
Are PFA Static Mixers more expensive than stainless steel ones? Yes, they are significantly more expensive due to the high cost of PFA resin and specialized manufacturing. However, in ultra-corrosive or high-purity applications, they often provide the lowest total cost of ownership by eliminating corrosion-related failures and contamination risks.

Note: PFA Static Mixers are the premium choice when maximum chemical resistance and ultra-high purity are required.
Their sealless, fluoropolymer construction makes them ideal for semiconductor, pharmaceutical, and aggressive chemical processes where conventional materials cannot perform reliably.

Advantages / Disadvantages

Advantages Disadvantages
  • Exceptional chemical resistance — nearly inert to all acids, solvents, bases, and oxidizers (including HF and aqua regia)
  • Ultra-high purity with extremely low extractables and leachables
  • Non-metallic construction eliminates risk of metallic contamination
  • Excellent non-stick surface reduces fouling and simplifies cleaning
  • Wide temperature range (-196°C to +260°C)
  • No moving parts — virtually maintenance-free
  • Ideal for semiconductor, pharmaceutical, and high-purity chemical processes
  • Long service life even in the most aggressive chemical environments
  • Significantly higher cost compared to stainless steel or other plastic static mixers
  • Limited pressure rating (typically up to 150 PSI / 10 bar)
  • Softer material requires careful handling and lower torque during installation
  • Not suitable for highly abrasive slurries (PFA surface can wear)
  • Lower mechanical strength than metal mixers
  • Size range is more limited than stainless steel options
  • Can be sensitive to certain mechanical stresses or rapid temperature changes

Note: PFA Static Mixers are the premium choice when maximum chemical resistance and ultra-high purity are required.
While they have a higher upfront cost and some mechanical limitations, they often provide the lowest total cost of ownership in highly corrosive or contamination-sensitive processes by eliminating corrosion, contamination, and frequent replacement issues.

Applications

PFA Static Mixers are specifically designed for ultra-corrosive, high-purity, or contamination-sensitive processes where even trace amounts of metal ions, particulates, or material degradation cannot be tolerated.
Their near-universal chemical resistance and extremely low extractables make them the preferred choice in industries with the strictest purity and safety requirements.

Applications of PFA Static Mixers

Industry / Application Typical Use Cases Purpose & Benefits
Semiconductor Manufacturing Ultra-pure chemical blending, wafer etching solutions (HF, BOE), photoresist mixing, CMP slurry dilution, piranha solution handling Prevents metallic contamination and maintains parts-per-billion purity levels required for advanced semiconductor processes.
Pharmaceutical & Biotechnology High-purity buffer preparation, API intermediate mixing, sterile solvent blending, vaccine production, bioreactor feed lines Ensures zero contamination and full compliance with FDA, GMP, and USP standards while handling aggressive cleaning chemicals.
Fine & Specialty Chemicals Strong acid dilution (HF, HNO₃, H₂SO₄), oxidizer mixing, halogenated solvent processing, reactive monomer blending Provides safe, long-term operation with chemicals that would rapidly corrode stainless steel or other plastics.
High-Purity Water Systems Ultrapure water (UPW) chemical dosing, point-of-use mixing, final polishing chemical injection Maintains the extreme purity levels required in semiconductor and pharmaceutical water systems.
Laboratory & Pilot Plants Research-scale reactions with aggressive reagents, pilot testing of new corrosive processes, handling of novel or hazardous compounds Offers flexibility and absolute containment when working with experimental or highly reactive chemicals.
Specialty Gas & Liquid Delivery High-purity gas humidification, corrosive gas scrubbing solutions, specialty liquid chemical distribution systems Prevents contamination and corrosion in critical delivery systems for electronics and specialty manufacturing.

PFA Static Mixers are chosen when the highest levels of chemical resistance and product purity are non-negotiable.
They excel in environments where stainless steel would corrode rapidly and other plastics would leach contaminants or degrade.
Their ability to handle the most aggressive chemicals while maintaining ultra-low extractables makes them indispensable in modern high-technology manufacturing.

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